File:RAP Features.jpg

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A1, Color image of the study eye at baseline. A2, Late-phase-angiogram showing intraretinal hyperfluorescence (hot spot) that leaks intensely. Petaloid hyperfluorescence can be observed (A3) in the fovea corresponding to (A4) the large intraretinal cysts noted on optical coherence tomography (OCT). Sub-retinal pigment epithelium (RPE) fluid (serous pigment epithelial detachment) also can be seen on OCT. B1, Color image of another patient at baseline showing intraretinal lipid. B2, B3, Angiograms showing (B2) an intense hyperfluorescent spot surrounded by (B3) hyperfluorescence in the sub- RPE space consistent with a serous pigment epithelial detachment. B4, Optical coherence tomography showing sub-RPE fluid (serous pigment epithelial detachment). B5, B6, B7, Images obtained at 2 years showing atrophic areas with (B8) corresponding signal penetration into the choroid on OCT.

From:Daniel E, Shaffer J, Ying GS, Grunwald JE, Martin DF, Jaffe GJ, Maguire MG; Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group. Outcomes in Eyes with Retinal Angiomatous Proliferation in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). Ophthalmology. 2016 Mar;123(3):609-16. doi: 10.1016/j.ophtha.2015.10.034. Epub 2015 Dec 8. PMID: 26681392; PMCID: PMC4766028.

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